Mitchel Ruigrok’s favorite structure is:

Human Apolipoprotein A-I

image

Source: RCSB Protein Databank
(http://www.rcsb.org/pdb/images/1av1_bio_r_500.jpg)

Why?

Human Apolipoprotein A-I has my favourite structure due to its unique shape: it has a Möbius-like shape. Of course, it is not an actual Möbius entity, but it looks quite interesting. In addition, Apolipoprotein A-I has an important function in the homeostasis of the human body. The protein promotes removal of cholesterol from the body by excreting it through the liver. In conclusion, the protein is interesting due to its unique shape (in comparison to many transmembrane proteins which all sort of look similar one way or the other) and due to its significance in promoting health in humans. Thank you! :)—Mitchel Ruigrok

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