Helen’s favorite structure is:

G-Protein Coupled Receptor Kinase 2

Why?

G-protein coupled receptor kinase 2 is an up and coming target for heart failure. It's crystal structure is useful for those of use working on designing inhibitors as therapeutics for heart failure. Mutagenesis studies have
shown that targeting specific amino acids is difficult. The crystal structure is very important as it is the entire conformation of the protein that we need to understand and the crystal structure helps to reveal this.—Helen

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